HMM Summary Page: TIGR00542

Functionputative hexulose-6-phosphate isomerase
Trusted Cutoff272.15
Domain Trusted Cutoff272.15
Noise Cutoff188.50
Domain Noise Cutoff188.50
Isology Typehypoth_equivalog
HMM Length279
Mainrole CategoryEnergy metabolism
Subrole CategorySugars
AuthorHaft DH
Entry DateOct 19 1999 4:29PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family shows similarity by PSI-BLAST to other isomerases. Putative identification as hexulose-6-phosphate isomerase is reported in Swiss-Prot, attributing a discussion in Genome Sci. Technol. 1:53-75(1996). This family is conserved at better than 40 % identity among the four known examples from three species: Escherichia coli (SgbU and SgaU), Haemophilus influenzae, and Mycoplasma pneumoniae. The rarity of the family, high level of conservation, and proposed catabolic role suggests lateral transfer may be a part of the evolutionary history of this protein.
ReferencesGA hmmsearch DR SWISSPROT; P37679; DR SWISSPROT; P39305; DR ECOCYC; EG12286; SGBU RN [1] RA REIZER J., CHARBIT A., REIZER A., SAIER M.H. JR.; RT "Novel phosphotransferases system genes revealed by bacterial genome analysis: operons encoding homologues of sugar-specific permease domains of the phosphotransferase system and pentose catabolic enzymes." RL GENOME SCI. TECHNOL. 1:53-75(1996). DR HAMAP; MF_01951; 18 of 19