HMM Summary Page: TIGR00541

Functionhistidine decarboxylase, pyruvoyl type
Trusted Cutoff346.65
Domain Trusted Cutoff346.65
Noise Cutoff200.50
Domain Noise Cutoff200.50
Isology Typeequivalog
EC Number4.1.1.22
HMM Length307
Mainrole CategoryEnergy metabolism
Subrole CategoryAmino acids and amines
Gene Ontology TermGO:0004398: histidine decarboxylase activity molecular_function
GO:0006547: histidine metabolic process biological_process
AuthorHaft DH
Entry DateOct 19 1999 4:29PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme converts histadine to histamine in a single step by catalyzing the release of CO2. This type is synthesized as an inactive single chain precursor, then cleaved into two chains. The Ser at the new N-terminus at the cleavage site is converted to a pyruvoyl group essential for activity. This type of histidine decarboxylase appears is known so far only in some Gram-positive bacteria, where it may play a role in amino acid catabolism. There is also a pyridoxal phosphate type histidine decarboxylase, as found in human, where histamine is a biologically active amine.
ReferencesA2 hmmalign AL ClustalW RM 90212559 RT Cloning, sequencing, expression, and site-directed mutagenesis of the gene from Clostridium perfringens encoding pyruvoyl-dependent histidine decarboxylase. RA van Poelje PD, Snell EE RL Biochemistry 1990 Jan 9;29(1):132-9
Genome PropertyGenProp0872: decarboxylation/antiport proton-motive cycle: histidine-histamine (HMM)