| Accession | TIGR00541 |
| Name | hisDCase_pyru |
| Function | histidine decarboxylase, pyruvoyl type |
| Trusted Cutoff | 346.65 |
| Domain Trusted Cutoff | 346.65 |
| Noise Cutoff | 200.50 |
| Domain Noise Cutoff | 200.50 |
| Isology Type | equivalog |
| EC Number | 4.1.1.22 |
| HMM Length | 307 |
| Mainrole Category | Energy metabolism |
| Subrole Category | Amino acids and amines |
| Gene Ontology Term | GO:0004398: histidine decarboxylase activity molecular_function |
| | GO:0006547: histidine metabolic process biological_process |
| Author | Haft DH |
| Entry Date | Oct 19 1999 4:29PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This enzyme converts histadine to histamine in a single step by catalyzing the release of CO2. This type is synthesized as an inactive single chain precursor, then cleaved into two chains. The Ser at the new N-terminus at the cleavage site is converted to a pyruvoyl group essential for activity. This type of histidine decarboxylase appears is known so far only in some Gram-positive bacteria, where it may play a role in amino acid catabolism. There is also a pyridoxal phosphate type histidine decarboxylase, as found in human, where histamine is a biologically active amine.
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| References | A2 hmmalign
AL ClustalW
RM 90212559
RT Cloning, sequencing, expression, and site-directed mutagenesis of the gene from Clostridium perfringens encoding pyruvoyl-dependent histidine decarboxylase.
RA van Poelje PD, Snell EE
RL Biochemistry 1990 Jan 9;29(1):132-9
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| Genome Property | GenProp0872: decarboxylation/antiport proton-motive cycle: histidine-histamine (HMM) |
