HMM Summary Page: TIGR00536

Functionmethyltransferase, HemK family
Trusted Cutoff115.50
Domain Trusted Cutoff115.50
Noise Cutoff73.45
Domain Noise Cutoff73.45
Isology Typesubfamily
HMM Length286
Mainrole CategoryProtein fate
Subrole CategoryProtein modification and repair
Gene Ontology TermGO:0008152: metabolic process biological_process
GO:0008276: protein methyltransferase activity molecular_function
AuthorHaft DH
Entry DateOct 19 1999 4:29PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase (Medline 95189105). Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain.
ReferencesA2 hmmalign GA hmmsearch RN [1] RM 99237242 RT Functional analysis of the hemK gene product involvement in protoporphyrinogen oxidase activity in yeast. RA Le Guen L, Santos R, Camadro JM RL FEMS Microbiol Lett 1999 Apr 1;173(1):175-82 RN [2] RM 95189105 RT Cloning and sequencing of a previously unidentified gene that is involved in the biosynthesis of heme in Escherichia coli. RA Nakayashiki T, Nishimura K, Inokuchi H RL Gene 1995 Feb 3;153(1):67-70 AL ClustalW
Genome PropertyGenProp0746: translation termination, bacterial (HMM-CLUST)