HMM Summary Page: TIGR00535

FunctionS-adenosylmethionine decarboxylase proenzyme
Trusted Cutoff233.15
Domain Trusted Cutoff233.15
Noise Cutoff127.30
Domain Noise Cutoff127.30
Isology Typeequivalog
EC Number4.1.1.50
HMM Length334
Mainrole CategoryCentral intermediary metabolism
Subrole CategoryPolyamine biosynthesis
Gene Ontology TermGO:0004014: adenosylmethionine decarboxylase activity molecular_function
GO:0006597: spermine biosynthetic process biological_process
GO:0008295: spermidine biosynthetic process biological_process
AuthorHaft DH
Entry DateOct 19 1999 4:29PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme is a key regulatory enzyme of the polyamine synthetic pathway. This protein is a pyruvoyl-dependent enzyme. The proenzyme is cleaved at a Ser residue that becomes a pyruvoyl group active site.
ReferencesA2 hmmalign AL ClustalW DR PROSITE; PDOC01038; S-adenosylmethionine decarboxylase signature;