HMM Summary Page: TIGR00534

Functionglucose-6-phosphate dehydrogenase assembly protein OpcA
Gene SymbolopcA
Trusted Cutoff256.25
Domain Trusted Cutoff256.25
Noise Cutoff93.75
Domain Noise Cutoff93.75
Isology Typeequivalog
HMM Length313
Mainrole CategoryProtein fate
Subrole CategoryProtein folding and stabilization
Gene Ontology TermGO:0006098: pentose-phosphate shunt biological_process
GO:0006461: protein complex assembly biological_process
AuthorHaft DH
Entry DateOct 19 1999 4:29PM
Last ModifiedDec 8 2011 10:43AM
CommentThe opcA gene is found immediately downstream of zwf, the glucose-6-phosphate dehydrogenase (G6PDH) gene, in a number of species, including Mycobacterium tuberculosis, Streptomyces coelicolor, Nostoc punctiforme, and Synechococcus sp. PCC 7942. In the latter, disruption of opcA was shown to block assembly of G6PDH into active oligomeric forms.
ReferencesRN [1] RM PMID:9639925 RT Multiple oligomeric forms of glucose-6-phosphate dehydrogenase in cyanobacteria and the role of OpcA in the assembly process. RA Sundaram S, Karakaya H, Scanlan DJ, Mann NH RL Microbiology 1998 Jun;144 ( Pt 6):1549-56