| Accession | TIGR00533 |
| Name | HMG_CoA_R_NADP |
| Function | hydroxymethylglutaryl-CoA reductase (NADPH) |
| Gene Symbol | hmgA |
| Trusted Cutoff | 441.80 |
| Domain Trusted Cutoff | 441.80 |
| Noise Cutoff | 204.70 |
| Domain Noise Cutoff | 204.70 |
| Isology Type | equivalog_domain |
| EC Number | 1.1.1.34 |
| HMM Length | 402 |
| Mainrole Category | Central intermediary metabolism |
| Subrole Category | Other |
| Gene Ontology Term | GO:0004420: hydroxymethylglutaryl-CoA reductase (NADPH) activity molecular_function |
| | GO:0008299: isoprenoid biosynthetic process biological_process |
| Author | Haft DH |
| Entry Date | Oct 19 1999 4:29PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This model represents archaeal examples of the enzyme hydroxymethylglutaryl-CoA reductase (NADP) (EC 1.1.1.34) and the catalytic domain of eukaryotic examples, which also contain a hydrophobic N-terminal domain. This enzyme synthesizes mevalonate, a precursor of isopentenyl pyrophosphate (IPP), a building block for the synthesis of cholesterol, isoprenoids, and other molecules. A related hydroxymethylglutaryl-CoA reductase, typified by an example from Pseudomonas mevalonii, is NAD-dependent and catabolic. |
| References | A2 hmmalign
DR PROSITE; PDOC00064; Hydroxymethylglutaryl-coenzyme A reductase signatures and profile
AL ClustalW |
| Genome Property | GenProp0047: IPP biosynthesis via mevalonate (HMM) |
