HMM Summary Page: TIGR00532

Functionhydroxymethylglutaryl-CoA reductase, degradative
Trusted Cutoff259.95
Domain Trusted Cutoff259.95
Noise Cutoff71.45
Domain Noise Cutoff71.45
Isology Typeequivalog
EC Number1.1.1.88
HMM Length395
Mainrole CategoryEnergy metabolism
Subrole CategoryOther
Gene Ontology TermGO:0004420: hydroxymethylglutaryl-CoA reductase (NADPH) activity molecular_function
GO:0016054: organic acid catabolic process biological_process
AuthorHaft DH
Entry DateOct 19 1999 4:29PM
Last ModifiedFeb 14 2011 3:27PM
CommentMost known examples of hydroxymethylglutaryl-CoA reductase are NADP-dependent (EC from eukaryotes and archaea, involved in the biosynthesis of mevalonate from 3-hydroxy-3-methylglutaryl-CoA. This model, in contrast, is built from the two examples in completed genomes of sequences closely related to the degradative, NAD-dependent hydroxymethylglutaryl-CoA reductase of Pseudomonas mevalonii, a bacterium that can use mevalonate as its sole carbon source.
ReferencesA2 hmmalign GA hmmsearch DR PROSITE; PDOC00064; Hydroxymethylglutaryl-coenzyme A reductase signatures and profile AL ClustalW RM 89255053 RT Cloning, sequencing, and overexpression of mvaA, which encodes Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl coenzyme A reductase. RA Beach MJ, Rodwell VW RL J Bacteriol 1989 Jun;171(6):2994-3001 DR SWISSPROT; P13702; MVAA_PSEMV;
Genome PropertyGenProp0047: IPP biosynthesis via mevalonate (HMM)