| Accession | TIGR00532 |
| Name | HMG_CoA_R_NAD |
| Function | hydroxymethylglutaryl-CoA reductase, degradative |
| Trusted Cutoff | 259.95 |
| Domain Trusted Cutoff | 259.95 |
| Noise Cutoff | 71.45 |
| Domain Noise Cutoff | 71.45 |
| Isology Type | equivalog |
| EC Number | 1.1.1.88 |
| HMM Length | 395 |
| Mainrole Category | Energy metabolism |
| Subrole Category | Other |
| Gene Ontology Term | GO:0004420: hydroxymethylglutaryl-CoA reductase (NADPH) activity molecular_function |
| | GO:0016054: organic acid catabolic process biological_process |
| Author | Haft DH |
| Entry Date | Oct 19 1999 4:29PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Most known examples of hydroxymethylglutaryl-CoA reductase are NADP-dependent (EC 1.1.1.34) from eukaryotes and archaea, involved in the biosynthesis of mevalonate from 3-hydroxy-3-methylglutaryl-CoA. This model, in contrast, is built from the two examples in completed genomes of sequences closely related to the degradative, NAD-dependent hydroxymethylglutaryl-CoA reductase of Pseudomonas mevalonii, a bacterium that can use mevalonate as its sole carbon source.
|
| References | A2 hmmalign
GA hmmsearch
DR PROSITE; PDOC00064; Hydroxymethylglutaryl-coenzyme A reductase signatures and profile
AL ClustalW
RM 89255053
RT Cloning, sequencing, and overexpression of mvaA, which encodes Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl coenzyme A reductase.
RA Beach MJ, Rodwell VW
RL J Bacteriol 1989 Jun;171(6):2994-3001
DR SWISSPROT; P13702; MVAA_PSEMV;
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| Genome Property | GenProp0047: IPP biosynthesis via mevalonate (HMM) |
