HMM Summary Page: TIGR00531

Functionacetyl-CoA carboxylase, biotin carboxyl carrier protein
Gene SymbolaccB
Trusted Cutoff115.20
Domain Trusted Cutoff115.20
Noise Cutoff92.85
Domain Noise Cutoff92.85
Isology Typeequivalog
HMM Length156
Mainrole CategoryFatty acid and phospholipid metabolism
Subrole CategoryBiosynthesis
Gene Ontology TermGO:0003989: acetyl-CoA carboxylase activity molecular_function
GO:0006633: fatty acid biosynthetic process biological_process
GO:0009317: acetyl-CoA carboxylase complex cellular_component
AuthorHaft DH
Entry DateOct 19 1999 4:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model is designed to identify biotin carboxyl carrier protein as a peptide of acetyl-CoA carboxylase. Scoring below the trusted cutoff is a related protein encoded in a region associated with polyketide synthesis in the prokaryote Saccharopolyspora hirsuta, and a reported chloroplast-encoded biotin carboxyl carrier protein that may be highly derived from the last common ancestral sequence. Scoring below the noise cutoff are biotin carboxyl carrier domains of other enzymes such as pyruvate carboxylase. The gene name is accB or fabE.
ReferencesA2 hmmalign GA hmmsearch RM 96363677 RT Structure of the biotinyl domain of acetyl-coenzyme A carboxylase determined by MAD phasing. RA Athappilly FK, Hendrickson WA RL Structure 1995 Dec 15;3(12):1407-19
Genome PropertyGenProp0214: acetyl-CoA carboxylase complex (HMM)