HMM Summary Page: TIGR00527

Functionglycine cleavage system H protein
Gene SymbolgcvH
Trusted Cutoff115.85
Domain Trusted Cutoff115.85
Noise Cutoff96.90
Domain Noise Cutoff96.90
Isology Typeequivalog
HMM Length129
Mainrole CategoryEnergy metabolism
Subrole CategoryAmino acids and amines
Gene Ontology TermGO:0003824: catalytic activity molecular_function
GO:0019464: glycine decarboxylation via glycine cleavage system biological_process
AuthorHaft DH
Entry DateOct 18 1999 5:03PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents the glycine cleavage system H protein, which shuttles the methylamine group of glycine from the P protein to the T protein. The mature protein is about 130 residues long and contains a lipoyl group covalently bound to a conserved Lys residue. The genome of Aquifex aeolicus contains one protein scoring above the trusted cutoff and clustering with other bacterial H proteins, and four more proteins clustering together and scoring below the trusted cutoff; it seems doubtful that all of these homologs are authentic H protein. The Chlamydial homolog of H protein is nearly as divergent as the Aquifex outgroup, is not accompanied by P and T proteins, is not included in the seed alignment, and consequently also scores below the trusted cutoff.
ReferencesA2 hmmalign AL clustalw
Genome PropertyGenProp0178: glycine cleavage system (HMM)