HMM Summary Page: TIGR00524

FunctioneIF-2B alpha/beta/delta-related uncharacterized proteins
Trusted Cutoff185.85
Domain Trusted Cutoff185.85
Noise Cutoff142.60
Domain Noise Cutoff142.60
Isology Typesubfamily
HMM Length303
Mainrole CategoryUnknown function
Subrole CategoryGeneral
AuthorHaft DH
Entry DateOct 18 1999 5:03PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM, eIF-2B_rel, describes half of a superfamily, where the other half consists of eukaryotic translation initiation factor 2B (eIF-2B) subunits alpha, beta, and delta. It is unclear whether the eIF-2B_rel set is monophyletic, or whether they are all more closely related to each other than to any eIF-2B subunit because the eIF-2B clade is highly derived. Members of this branch of the family are all uncharacterized with respect to function and are found in the Archaea, Bacteria, and Eukarya, although a number are described as putative translation intiation factor components. Proteins found by eIF-2B_rel include at least three clades, including a set of uncharacterized eukaryotic proteins, a set found in some but not all Archaea, and a set universal so far among the Archaea and closely related to several uncharacterized bacterial proteins.
ReferencesRM 98188271 RT Archaeal translation initiation revisited: the initiation factor 2 and eukaryotic initiation factor 2B alpha-beta-delta subunit families. RA Kyrpides NC, Woese CR RL Proc Natl Acad Sci U S A 1998 Mar 31;95(7):3726-30 DR HAMAP; MF_01678; 159 of 164