HMM Summary Page: TIGR00522

Functiondiphthine synthase
Gene Symboldph5
Trusted Cutoff114.30
Domain Trusted Cutoff114.30
Noise Cutoff113.75
Domain Noise Cutoff113.75
Isology Typeequivalog
EC Number2.1.1.98
HMM Length258
Mainrole CategoryProtein fate
Subrole CategoryProtein modification and repair
Gene Ontology TermGO:0004164: diphthine synthase activity molecular_function
GO:0017183: peptidyl-diphthamide biosynthetic process from peptidyl-histidine biological_process
AuthorHaft DH
Entry DateOct 18 1999 5:03PM
Last ModifiedFeb 14 2011 3:27PM
CommentAlternate name: diphthamide biosynthesis S-adenosylmethionine-dependent methyltransferase. This protein participates in the modification of a specific His of elongation factor 2 of eukarotes and Archaea to diphthamide. The protein was characterized in Saccharomyces cerevisiae and designated DPH5.
ReferencesRM 92375071 RT DPH5, a methyltransferase gene required for diphthamide biosynthesis in Saccharomyces cerevisiae. RA Mattheakis LC, Shen WH, Collier RJ RL Mol Cell Biol 1992 Sep;12(9):4026-37 DR HAMAP; MF_01084; 32 of 38
Genome PropertyGenProp0831: archaeal core gene set, exactly 1 per genome (HMM)