| Accession | TIGR00521 |
| Name | coaBC_dfp |
| Function | phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase |
| Gene Symbol | coaBC |
| Trusted Cutoff | 219.70 |
| Domain Trusted Cutoff | 219.70 |
| Noise Cutoff | 211.10 |
| Domain Noise Cutoff | 211.10 |
| Isology Type | equivalog |
| EC Number | 4.1.1.36 6.3.2.5 |
| HMM Length | 392 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Pantothenate and coenzyme A |
| Gene Ontology Term | GO:0004632: phosphopantothenate--cysteine ligase activity molecular_function |
| | GO:0004633: phosphopantothenoylcysteine decarboxylase activity molecular_function |
| | GO:0015937: coenzyme A biosynthetic process biological_process |
| | GO:0015939: pantothenate metabolic process biological_process |
| Author | Haft DH |
| Entry Date | Oct 18 1999 5:03PM |
| Last Modified | Aug 24 2011 4:20PM |
| Comment | This HMM represents a bifunctional enzyme that catalyzes the second and third steps (cysteine ligation, EC 6.3.2.5, and decarboxylation, EC 4.1.1.36) in the biosynthesis of coenzyme A (CoA) from pantothenate in bacteria. In early descriptions of this flavoprotein, a ts mutation in one region of the protein appeared to cause a defect in DNA metaobolism rather than an increased need for the pantothenate precursor beta-alanine. This protein was then called dfp, for DNA/pantothenate metabolism flavoprotein. The authors responsible for detecting phosphopantothenate--cysteine ligase activity suggest renaming this bifunctional protein coaBC for its role in CoA biosynthesis. This enzyme contains the FMN cofactor, but no FAD or pyruvoyl group. The amino-terminal region contains the phosphopantothenoylcysteine decarboxylase activity. |
| References | RN [1]
RM 11278255
RT Phosphopantothenoylcysteine synthetase from Escherichia coli. Identification and characterization of the last unidentified coenzyme A biosynthetic enzyme in bacteria.
RA Strauss E, Kinsland C, Ge Y, McLafferty FW, Begley TP.
RL J Biol Chem 2001 Apr 27;276(17):13513-6
RN [2]
RM 88115193
RT beta-Alanine auxotrophy associated with dfp, a locus affecting DNA synthesis in Escherichia coli.
RA Spitzer ED, Jimenez-Billini HE, Weiss B
RL J Bacteriol 1988 Feb;170(2):872-6 |
| Genome Property | GenProp0171: coenzyme A biosynthesis from pantothenate (HMM) |
| | GenProp0171: coenzyme A biosynthesis from pantothenate (HMM) |
