HMM Summary Page: TIGR00519

FunctionL-asparaginase, type I
Trusted Cutoff260.50
Domain Trusted Cutoff260.50
Noise Cutoff190.10
Domain Noise Cutoff190.10
Isology Typesubfamily
EC Number3.5.1.1
HMM Length337
AuthorHaft DH
Entry DateOct 18 1999 5:03PM
Last ModifiedFeb 21 2012 12:12PM
CommentTwo related families of asparaginase are designated type I and type II according to the terminology in E. coli, which has both: L-asparaginase I is a low-affinity enzyme found in the cytoplasm, while L-asparaginase II is a high-affinity secreted enzyme synthesized with a cleavable signal sequence. This model describes L-asparaginases related to type I of E. coli. Archaeal putative asparaginases are of this type but contain an extra ~ 80 residues in a conserved N-terminal region. These archaeal homologs are included in this model.
ReferencesDR PFAM; PF00710; Asparaginase DR PROSITE; PDOC0013; Asparaginase / glutaminase active sites signatures DR HAMAP; MF_00586; 29 of 29