HMM Summary Page: TIGR00517

Functionacyl carrier protein
Gene SymbolacpP
Trusted Cutoff70.45
Domain Trusted Cutoff70.45
Noise Cutoff26.40
Domain Noise Cutoff26.40
Isology Typeequivalog
HMM Length77
Mainrole CategoryFatty acid and phospholipid metabolism
Subrole CategoryBiosynthesis
Gene Ontology TermGO:0000036: acyl carrier activity molecular_function
GO:0006633: fatty acid biosynthetic process biological_process
AuthorHaft DH
Entry DateOct 18 1999 5:03PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis small protein has phosphopantetheine covalently bound to a Ser residue. It acts as a carrier of the growing fatty acid chain, which is bound to the prosthetic group, during fatty acid biosynthesis. Homologous phosphopantetheine-binding domains are found in longer proteins. Acyl carrier proteins scoring above the noise cutoff but below the trusted cutoff may be specialized versions. These include those involved in mycolic acid biosynthesis in the Mycobacteria, lipid A biosynthesis in Rhizobium, actinorhodin polyketide synthesis in Streptomyces coelicolor, etc. This protein is not found in the Archaea. Gene name acpP. S (Ser) at position 37 in the seed alignment, in the motif DSLD, is the phosphopantetheine attachment site.
ReferencesDR PROSITE; PDOC00012; Phosphopantetheine attachment site DR HAMAP; MF_01217; 345 of 374
Genome PropertyGenProp1104: acyl carrier protein phosphopantetheinylation (HMM)