HMM Summary Page: TIGR00516

Functionholo-[acyl-carrier-protein] synthase
Gene SymbolacpS
Trusted Cutoff59.80
Domain Trusted Cutoff59.80
Noise Cutoff35.25
Domain Noise Cutoff35.25
Isology Typeequivalog_domain
EC Number2.7.8.7
HMM Length125
Mainrole CategoryFatty acid and phospholipid metabolism
Subrole CategoryBiosynthesis
Gene Ontology TermGO:0008610: lipid biosynthetic process biological_process
GO:0008897: holo-[acyl-carrier-protein] synthase activity molecular_function
AuthorHaft DH
Entry DateOct 18 1999 5:03PM
Last ModifiedFeb 14 2011 3:27PM
CommentFormerly dpj. This enzyme adds the prosthetic group, phosphopantethiene, to the acyl carrier protein (ACP) apo-enzyme to generate the holo-enzyme. Related phosphopantethiene--protein transferases also exist. There is an orthologous domain in eukaryotic proteins.
ReferencesRM 96027548 RT Cloning, overproduction, and characterization of the Escherichia coli holo-acyl carrier protein synthase. RA Lambalot RH, Walsh CT RL J Biol Chem 1995 Oct 20;270(42):24658-61 DR HAMAP; MF_00101; 359 of 394
Genome PropertyGenProp1104: acyl carrier protein phosphopantetheinylation (HMM)