HMM Summary Page: TIGR00514

Functionacetyl-CoA carboxylase, biotin carboxylase subunit
Gene SymbolaccC
Trusted Cutoff626.50
Domain Trusted Cutoff626.50
Noise Cutoff550.45
Domain Noise Cutoff550.45
Isology Typeequivalog
EC Number6.3.4.14
HMM Length449
Mainrole CategoryFatty acid and phospholipid metabolism
Subrole CategoryBiosynthesis
Gene Ontology TermGO:0003989: acetyl-CoA carboxylase activity molecular_function
GO:0004075: biotin carboxylase activity molecular_function
GO:0006633: fatty acid biosynthetic process biological_process
GO:0009317: acetyl-CoA carboxylase complex cellular_component
AuthorHaft DH
Entry DateOct 18 1999 5:03PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents the biotin carboxylase subunit found usually as a component of acetyl-CoA carboxylase. Acetyl-CoA carboxylase is designated EC and this component, biotin carboxylase, has its own designation, EC Homologous domains are found in eukaryotic forms of acetyl-CoA carboxylase and in a number of other carboxylases (e.g. pyruvate carboxylase), but seed members and trusted cutoff are selected so as to exclude these. In some systems, the biotin carboxyl carrier protein and this protein (biotin carboxylase) may be shared by different carboxyltransferases. However, this model is not intended to identify the biotin carboxylase domain of propionyl-coA carboxylase. The model should hit the full length of proteins, except for chloroplast transit peptides in plants. If it hits a domain only of a longer protein, there may be a problem with the identification.
ReferencesA2 hmmalign GA hmmsearch
Genome PropertyGenProp0214: acetyl-CoA carboxylase complex (HMM)