HMM Summary Page: TIGR00512

FunctionS-methyl-5-thioribose-1-phosphate isomerase
Gene SymbolmtnA
Trusted Cutoff279.00
Domain Trusted Cutoff279.00
Noise Cutoff234.35
Domain Noise Cutoff234.35
Isology Typeequivalog
EC Number5.3.1.23
HMM Length335
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryAspartate family
Gene Ontology TermGO:0019509: L-methionine salvage from methylthioadenosine biological_process
GO:0046523: S-methyl-5-thioribose-1-phosphate isomerase activity molecular_function
AuthorHaft DH
Entry DateOct 18 1999 5:03PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe delineation of this family was based in part on a discussion and neighbor-joining phylogenetic study, by Kyrpides and Woese, of archaeal and other proteins homologous to the alpha, beta, and delta subunits of eukaryotic initiation factor 2B (eIF-2B), a five-subunit molecule that catalyzes GTP recycling for eIF-2. This clade is now recognized to include the methionine salvage pathway enzyme MtnA.
ReferencesRN [2] RM 98188271 RT Archaeal translation initiation revisited: the initiation factor 2 and eukaryotic initiation factor 2B alpha-beta-delta subunit families. RA Kyrpides NC, Woese CR RL Proc Natl Acad Sci U S A 1998 Mar 31;95(7):3726-30 DR HAMAP; MF_01678; 159 of 164
Genome PropertyGenProp0729: methionine salvage from methylthioadenosine (HMM)