HMM Summary Page: TIGR00511

Functionribose-1,5-bisphosphate isomerase, e2b2 family
Trusted Cutoff314.10
Domain Trusted Cutoff314.10
Noise Cutoff246.10
Domain Noise Cutoff246.10
Isology Typeequivalog
EC Number5.3.1.-
HMM Length301
Mainrole CategoryEnergy metabolism
Subrole CategoryOther
Gene Ontology TermGO:0016861: intramolecular oxidoreductase activity, interconverting aldoses and ketoses molecular_function
GO:0046033: AMP metabolic process biological_process
AuthorHaft DH
Entry DateOct 18 1999 5:02PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe delineation of this family was based originally, in part, on a discussion and neighbor-joining phylogenetic study by Kyrpides and Woese of archaeal and other proteins homologous to the alpha, beta, and delta subunits of eukaryotic initiation factor 2B (eIF-2B), a five-subunit molecule that catalyzes GTP recycling for eIF-2. Recently, Sato, et al. assigned the function ribulose-1,5 bisphosphate isomerase.
ReferencesRN [1] RM 98188271 RT Archaeal translation initiation revisited: the initiation factor 2 and eukaryotic initiation factor 2B alpha-beta-delta subunit families. RA Kyrpides NC, Woese CR RL Proc Natl Acad Sci U S A 1998 Mar 31;95(7):3726-30 RN [2] RM PMID: 17303759 RT Archaeal type III RuBisCOs function in a pathway for AMP metabolism. RA Sato T, Atomi H, Imanaka T RL Science. 2007 Feb 16;315(5814):1003-6.
Genome PropertyGenProp0728: AMP metabolism using type III Rubisco (HMM)