HMM Summary Page: TIGR00509

Functionmolybdopterin guanine dinucleotide-containing S/N-oxide reductases
Trusted Cutoff1017.55
Domain Trusted Cutoff1017.55
Noise Cutoff232.15
Domain Noise Cutoff232.15
Isology Typesubfamily
HMM Length772
AuthorHaft DH
Entry DateOct 15 1999 3:12PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme family shares sequence similarity and a requirement for a molydenum cofactor as the only prosthetic group. The form of the cofactor is a single molybdenum atom coordinated by two molybdopterin guanine dinucleotide molecules. Members of the family include biotin sulfoxide reductase, dimethylsulfoxide reductase, and trimethylamine-N-oxide reductase, although a single member may show all those activities and related activities; it may not be possible to resolve the primary function for members of this family by sequence comparison alone. A number of similar molybdoproteins in which the N-terminal region contains a CXXXC motif and may bind an iron-sulfur cluster are excluded from this set, including formate dehydrogenases and nitrate reductases. Also excluded is the A chain of a heteromeric, anaerobic DMSO reductase, which also contains the CXXXC motif.
ReferencesA2 hmmalign GA hmmsearch RM 97166177 RT Biotin sulfoxide reductase. Heterologous expression and characterization of a functional molybdopterin guanine dinucleotide-containing enzyme. RA Pollock VV, Barber MJ RL J Biol Chem 1997 Feb 7;272(6):3355-62