HMM Summary Page: TIGR00507

Functionshikimate dehydrogenase
Gene SymbolaroE
Trusted Cutoff200.20
Domain Trusted Cutoff200.20
Noise Cutoff124.50
Domain Noise Cutoff124.50
Isology Typeequivalog_domain
EC Number1.1.1.25
HMM Length270
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryAromatic amino acid family
Gene Ontology TermGO:0004764: shikimate 3-dehydrogenase (NADP+) activity molecular_function
GO:0009423: chorismate biosynthetic process biological_process
AuthorHaft DH
Entry DateOct 12 1999 5:46PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM finds proteins from prokaryotes and functionally equivalent domains from larger, multifunctional proteins of fungi and plants. Below the trusted cutoff of 180, but above the noise cutoff of 20, are the putative shikimate dehydrogenases of Thermotoga maritima and Mycobacterium tuberculosis, and uncharacterized paralogs of shikimate dehydrogenase from E. coli and H. influenzae. The related enzyme quinate 5-dehydrogenase scores below the noise cutoff. A neighbor-joining tree, constructed with quinate 5-dehydrogenases as the outgroup, shows the Clamydial homolog as clustering among the shikimate dehydrogenases, although the sequence is unusual in the degree of sequence divergence and the presence of an additional N-terminal domain.
ReferencesDR HAMAP; MF_00222; 310 of 327
Genome PropertyGenProp0001: chorismate biosynthesis via shikimate (HMM)