HMM Summary Page: TIGR00504

Functionpyroglutamyl-peptidase I
Gene Symbolpcp
Trusted Cutoff201.75
Domain Trusted Cutoff201.75
Noise Cutoff113.65
Domain Noise Cutoff113.65
Isology Typeequivalog
EC Number3.4.19.3
HMM Length213
Mainrole CategoryProtein fate
Subrole CategoryDegradation of proteins, peptides, and glycopeptides
Gene Ontology TermGO:0004219: pyroglutamyl-peptidase I activity molecular_function
GO:0030163: protein catabolic process biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentAlternate names include pyroglutamate aminopeptidase, pyrrolidone-carboxylate peptidase, and 5-oxoprolyl-peptidase. It removes pyroglutamate (pyrrolidone-carboxylate, a modified glutamine) that can otherwise block hydrolysis of a polypeptide at the amino end, and so can be extremely useful in the biochemical studies of proteins. The biological role in the various species in which it is found is not fully understood. The enzyme appears to be a homodimer. It does not closely resemble any other peptidases.
ReferencesSE TIGR GA hmmls AL clustalw DR HAMAP; MF_00417; 97 of 102