HMM Summary Page: TIGR00503

Functionpeptide chain release factor 3
Gene SymbolprfC
Trusted Cutoff466.95
Domain Trusted Cutoff466.95
Noise Cutoff327.25
Domain Noise Cutoff327.25
Isology Typeequivalog
HMM Length527
Mainrole CategoryProtein synthesis
Subrole CategoryTranslation factors
Gene Ontology TermGO:0003747: translation release factor activity molecular_function
GO:0005525: GTP binding molecular_function
GO:0006415: translational termination biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis translation releasing factor, RF-3 (prfC) was originally described as stop codon-independent, in contrast to peptide chain release factor 1 (RF-1, prfA) and RF-2 (prfB). RF-1 and RF-2 are closely related to each other, while RF-3 is similar to elongation factors EF-Tu and EF-G; RF-1 is active at UAA and UAG and RF-2 is active at UAA and UGA. More recently, RF-3 was shown to be active primarily at UGA stop codons in E. coli. All bacteria and organelles have RF-1. The Mycoplasmas and organelles, which translate UGA as Trp rather than as a stop codon, lack RF-2. RF-3, in contrast, seems to be rare among bacteria and is found so far only in Escherichia coli and some other gamma subdivision Proteobacteria, in Synechocystis PCC6803, and in Staphylococcus aureus.
ReferencesRM Medline; 98119823; RM Medline; 95256223; SE TIGR GA hmmls AL clustalw DR HAMAP; MF_00072; 214 of 218
Genome PropertyGenProp0746: translation termination, bacterial (HMM)