HMM Summary Page: TIGR00501

Functionmethionine aminopeptidase, type II
Gene Symbolmap
Trusted Cutoff222.65
Domain Trusted Cutoff222.65
Noise Cutoff184.60
Domain Noise Cutoff184.60
Isology Typeequivalog
EC Number3.4.11.18
HMM Length295
Mainrole CategoryProtein fate
Subrole CategoryProtein modification and repair
Gene Ontology TermGO:0004239: methionyl aminopeptidase activity molecular_function
GO:0006464: protein modification process biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:08PM
Last ModifiedFeb 14 2011 3:27PM
CommentMethionine aminopeptidase (map) is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. The role of this protein in general is to produce the mature amino end of cytosolic proteins by removing the N-terminal methionine. This model describes type II, among which the eukaryotic members typically have an N-terminal extension not present in archaeal members. It can act cotranslationally. The enzyme from rat has been shown to associate with translation initiation factor 2 (IF-2) and may have a role in translational regulation.
ReferencesA2 hmmalign RM Medline; 98060511; RM Medline; 95372350; SE TIGR AL clustalw BD 0551