HMM Summary Page: TIGR00500

Functionmethionine aminopeptidase, type I
Gene Symbolmap
Trusted Cutoff171.35
Domain Trusted Cutoff171.35
Noise Cutoff130.85
Domain Noise Cutoff130.85
Isology Typeequivalog
EC Number3.4.11.18
HMM Length247
Mainrole CategoryProtein fate
Subrole CategoryProtein modification and repair
Gene Ontology TermGO:0004239: methionyl aminopeptidase activity molecular_function
GO:0006464: protein modification process biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:08PM
Last ModifiedFeb 14 2011 3:27PM
CommentMethionine aminopeptidase is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. This model describes type I. The role of this protein in general is to produce the mature form of cytosolic proteins by removing the N-terminal methionine.
ReferencesA2 hmmalign SE TIGR AL clustalw BD 0551