HMM Summary Page: TIGR00492

Functionalanine racemase
Gene Symbolalr
Trusted Cutoff168.00
Domain Trusted Cutoff168.00
Noise Cutoff129.90
Domain Noise Cutoff129.90
Isology Typeequivalog
EC Number5.1.1.1
HMM Length369
Mainrole CategoryCell envelope
Subrole CategoryBiosynthesis and degradation of murein sacculus and peptidoglycan
Gene Ontology TermGO:0008784: alanine racemase activity molecular_function
GO:0009252: peptidoglycan biosynthetic process biological_process
AuthorAnolik RT, Richardson DL
Entry DateApr 20 1999 2:06PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme interconverts L-alanine and D-alanine. Its primary function is to generate D-alanine for cell wall formation. With D-alanine-D-alanine ligase, it makes up the D-alanine branch of the peptidoglycan biosynthetic route. It is a monomer with one pyridoxal phosphate per subunit. In E. coli, the ortholog is duplicated so that a second isozyme, DadX, is present. DadX, a paralog of the biosynthetic Alr, is induced by D- or L-alanine and is involved in catabolism.
ReferencesDR PROSITE; PDOC00332; SE TIGR GA hmmls AL clustalw DR HAMAP; MF_01201; 227 of 233
Genome PropertyGenProp0158: peptidoglycan(murein) biosynthesis (HMM)