HMM Summary Page: TIGR00491

Functiontranslation initiation factor aIF-2
Gene SymbolinfB
Trusted Cutoff554.75
Domain Trusted Cutoff554.75
Noise Cutoff393.05
Domain Noise Cutoff393.05
Isology Typeequivalog
HMM Length594
Mainrole CategoryProtein synthesis
Subrole CategoryTranslation factors
Gene Ontology TermGO:0003743: translation initiation factor activity molecular_function
GO:0006413: translational initiation biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:06PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes archaeal and eukaryotic orthologs of bacterial IF-2. Like IF-2, it helps convey the initiator tRNA to the ribosome, although the initiator is N-formyl-Met in bacteria and Met here. This protein is not closely related to the subunits of eIF-2 of eukaryotes, which is also involved in the initiation of translation. The aIF-2 of Methanococcus jannaschii contains a large intein interrupting a region of very strongly conserved sequence very near the amino end; the alignment generated by this HMM does not correctly align the sequences from Methanococcus jannaschii and Pyrococcus horikoshii in this region.
ReferencesDR MUID 98288357 SE TIGR GA hmmls DR HAMAP; MF_00100; 43 of 608
Genome PropertyGenProp0815: archaeal-only core gene set (HMM)
GenProp0831: archaeal core gene set, exactly 1 per genome (HMM)