HMM Summary Page: TIGR00490

Functiontranslation elongation factor aEF-2
Trusted Cutoff738.45
Domain Trusted Cutoff738.45
Noise Cutoff346.65
Domain Noise Cutoff346.65
Isology Typeequivalog
HMM Length720
Mainrole CategoryProtein synthesis
Subrole CategoryTranslation factors
Gene Ontology TermGO:0003746: translation elongation factor activity molecular_function
GO:0006414: translational elongation biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:06PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents archaeal elongation factor 2, a protein more similar to eukaryotic EF-2 than to bacterial EF-G, both in sequence similarity and in sharing with eukaryotes the property of having a diphthamide (modified His) residue at a conserved position. The diphthamide can be ADP-ribosylated by diphtheria toxin in the presence of NAD.
ReferencesSE TIGR GA hmmls DR HAMAP; MF_00054; 44 of 618
Genome PropertyGenProp0831: archaeal core gene set, exactly 1 per genome (HMM)