| Accession | TIGR00485 |
| Name | EF-Tu |
| Function | translation elongation factor Tu |
| Gene Symbol | tuf |
| Trusted Cutoff | 522.40 |
| Domain Trusted Cutoff | 522.40 |
| Noise Cutoff | 135.30 |
| Domain Noise Cutoff | 135.30 |
| Isology Type | equivalog |
| HMM Length | 394 |
| Mainrole Category | Protein synthesis |
| Subrole Category | Translation factors |
| Gene Ontology Term | GO:0003746: translation elongation factor activity molecular_function |
| | GO:0006414: translational elongation biological_process |
| Author | Haft DH |
| Entry Date | Apr 20 1999 2:03PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM models orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts, one of several GTP-binding translation factors found by the more general pfam HMM GTP_EFTU. The eukaryotic conterpart, eukaryotic translation elongation factor 1 (eEF-1 alpha), is excluded from this model. EF-Tu is one of the most abundant proteins in bacteria, as well as one of the most highly conserved, and in a number of species the gene is duplicated with identical function. When bound to GTP, EF-Tu can form a complex with any (correctly) aminoacylated tRNA except those for initiation and for selenocysteine, in which case EF-Tu is replaced by other factors. Transfer RNA is carried to the ribosome in these complexes for protein translation. |
| References | SE TIGR
GA hmmls
AL clustalw
DR HAMAP; MF_00118; 685 of 762 |
| Genome Property | GenProp0741: translation elongation, bacterial (HMM) |
| | GenProp0800: bacterial core gene set, 1 or more per genome (HMM) |
