HMM Summary Page: TIGR00482

Functionnicotinate (nicotinamide) nucleotide adenylyltransferase
Gene SymbolnadD
Trusted Cutoff112.45
Domain Trusted Cutoff112.45
Noise Cutoff63.85
Domain Noise Cutoff63.85
Isology Typeequivalog
EC Number2.7.7.18
HMM Length194
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryPyridine nucleotides
Gene Ontology TermGO:0000309: nicotinamide-nucleotide adenylyltransferase activity molecular_function
GO:0004515: nicotinate-nucleotide adenylyltransferase activity molecular_function
GO:0005737: cytoplasm cellular_component
GO:0009435: NAD biosynthetic process biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:06PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents the predominant bacterial/eukaryotic adenylyltransferase for nicotinamide-nucleotide, its deamido form nicotinate nucleotide, or both. The first activity, nicotinamide-nucleotide adenylyltransferase (EC, synthesizes NAD by the salvage pathway, while the second, nicotinate-nucleotide adenylyltransferase (EC synthesizes the immediate precursor of NAD by the de novo pathway. In E. coli, NadD activity is biased toward the de novo pathway while salvage activity is channeled through the multifunctional NadR protein, but this division of labor may be exceptional. The given name of this model, nicotinate (nicotinamide) nucleotide adenylyltransferase, reflects the lack of absolute specificity with respect to substrate amidation state in most species.
ReferencesSE TIGR AL clustalw_manual DR HAMAP; MF_00244; 278 of 287
Genome PropertyGenProp0057: NAD(P) biosynthesis from L-aspartate and DHAP (HMM)