HMM Summary Page: TIGR00479

Function23S rRNA (uracil-5-)-methyltransferase RumA
Gene SymbolrumA
Trusted Cutoff183.55
Domain Trusted Cutoff183.55
Noise Cutoff159.95
Domain Noise Cutoff159.95
Isology Typeequivalog
EC Number2.1.1.-
HMM Length432
Mainrole CategoryProtein synthesis
Subrole CategorytRNA and rRNA base modification
Gene Ontology TermGO:0000154: rRNA modification biological_process
GO:0008649: rRNA methyltransferase activity molecular_function
AuthorLoftus BJ, Haft DH
Entry DateApr 20 1999 2:10PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis protein family was first proposed to be RNA methyltransferases by homology to the TrmA family. The member from E. coli has now been shown to act as the 23S RNA methyltransferase for the conserved U1939. The gene is now designated rumA and was previously designated ygcA.
ReferencesRM 11779873 RT Characterization of the 23 S ribosomal RNA m5U1939 methyltransferase from Escherichia coli. RA Agarwalla S, Kealey JT, Santi DV, Stroud RM. RL J Biol Chem. 2002 Mar 15;277(11):8835-40. DR SWISSPROT; P55135; Escherichia coli DR PROSITE; PDOC00945; DR ECOCYC; EG11247; DR HAMAP; MF_01010; 104 of 105