HMM Summary Page: TIGR00478

AccessionTIGR00478
Nametly
FunctionTlyA family rRNA methyltransferase/putative hemolysin
Trusted Cutoff185.80
Domain Trusted Cutoff185.80
Noise Cutoff118.60
Domain Noise Cutoff118.60
Isology Typesubfamily
HMM Length228
Mainrole CategoryUnknown function
Subrole CategoryGeneral
AuthorLoftus BJ, Haft DH
Entry DateApr 20 1999 2:10PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family include TlyA from Mycobacterium tuberculosis, an rRNA methylase whose modifications are necessary to confer sensitivity to ribosome-targeting antibiotics capreomycin and viomycin. Homology supports identification as a methyltransferase. However, a parallel literature persists in calling some members hemolysins. Hemolysins are exotoxins that attack blood cell membranes and cause cell rupture, often by forming a pore in the membrane. A recent study (2013) on SCO1782 from Streptomyces coelicolor shows hemolysin activity as earlier described for a homolog from the spirochete Serpula (Treponema) hyodysenteriae and one from Mycobacterium tuberculosis.
ReferencesDR EGAD:20008, SP:Q06803, (UI: 92112315), EGAD:128425 SE TIGR RN [1] RM PMID:22779429 RT Capreomycin susceptibility is increased by TlyA-directed 2'-O-methylation on both ribosomal subunits. RA Monshupanee T, Johansen SK, Dahlberg AE, Douthwaite S RL Mol Microbiol. 2012 Sep;85(6):1194-203. RN [2] RM PMID: 1730486 RT Cloning and expression of a Serpula (Treponema) hyodysenteriae hemolysin gene. RA Muir S, Koopman MB, Libby SJ, Joens LA, Heffron F, Kusters JG RL Infect Immun. 1992 Feb;60(2):529-35. RN [3] RM PMID: 9611795 RT Characterization of a haemolysin from Mycobacterium tuberculosis with homology to a virulence factor of Serpulina hyodysenteriae. RA Wren BW, Stabler RA, Das SS, Butcher PD, Mangan JA, Clarke JD, Casali N, Parish T, Stoker NG RL Microbiology. 1998 May;144 ( Pt 5):1205-11. Mycobacterium tuberculosis with homology to a virulence factor of Serpulina hyodysenteriae. RA Wren BW, Stabler RA, Das SS, Butcher PD, Mangan JA, Clarke JD, Casali N, Parish T, Stoker NG RL Microbiology. 1998 May;144 ( Pt 5):1205-11.