HMM Summary Page: TIGR00476

Functionselenide, water dikinase
Gene SymbolselD
Trusted Cutoff125.00
Domain Trusted Cutoff125.00
Noise Cutoff120.00
Domain Noise Cutoff120.00
Isology Typeequivalog
EC Number2.7.9.3
HMM Length311
Gene Ontology TermGO:0001887: selenium compound metabolic process biological_process
GO:0004756: selenide, water dikinase activity molecular_function
AuthorHaft DH
Entry DateApr 20 1999 2:09PM
Last ModifiedAug 28 2014 11:53AM
CommentIn prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements: SelC is the tRNA itself, SelD acts as a donor of reduced selenium, SelA modifies a serine residue on SelC into selenocysteine, and SelB is a selenocysteine-specific translation elongation factor. 3-prime or 5-prime non-coding elements of mRNA have been found as probable structures for directing selenocysteine incorporation. This HMM describes SelD, known as selenophosphate synthetase, selenium donor protein, and selenide,water dikinase. SelD provides reduced selenium for the selenium transferase SelA. This protein itself contains selenocysteine in many species; any sequence scoring above the trusted cutoff but not aligning to the beginning of the HMM is likely have selenocysteine residue incorrectly interpreted as a stop codon upstream of the given sequence. The SelD protein also provides selenophosphate for the enzyme tRNA 2-selenouridine synthase, which catalyzes a tRNA base modification. It also contributes to selenium incorporation by selenium-dependent molybdenum hydroxylases (SDMH), in genomes with the marker TIGR03309. All genomes with SelD should make selenocysteine, selenouridine, SDMH, or some combination.
ReferencesDR HAMAP; MF_00625; 70 of 70
Genome PropertyGenProp0016: selenocysteine system (HMM)
GenProp0692: selenouridine-containing tRNA (HMM)
GenProp0726: selenium-dependent molybdenum hydroxylase system (HMM)