HMM Summary Page: TIGR00475

Functionselenocysteine-specific translation elongation factor
Gene SymbolselB
Trusted Cutoff242.25
Domain Trusted Cutoff242.25
Noise Cutoff229.00
Domain Noise Cutoff229.00
Isology Typeequivalog
HMM Length581
Mainrole CategoryProtein synthesis
Subrole CategoryTranslation factors
Gene Ontology TermGO:0001514: selenocysteine incorporation biological_process
GO:0003746: translation elongation factor activity molecular_function
GO:0006414: translational elongation biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentIn prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements: SelC is the tRNA itself, SelD acts as a donor of reduced selenium, SelA modifies a serine residue on SelC into selenocysteine, and SelB is a selenocysteine-specific translation elongation factor. 3-prime or 5-prime non-coding elements of mRNA have been found as probable structures for directing selenocysteine incorporation. This HMM describes the elongation factor SelB, a close homolog rf EF-Tu. It may function by replacing EF-Tu. A C-terminal domain not found in EF-Tu is in all SelB sequences in the seed alignment except that from Methanococcus jannaschii. This model does not find an equivalent protein for eukaryotes.
ReferencesSE TIGR RM 12486046 RT Inactivation of the selB gene in Methanococcus maripaludis: effect on synthesis of selenoproteins and their sulfur-containing homologs. RA Rother M, Mathes I, Lottspeich F, Bock A. RL J Bacteriol. 2003 Jan;185(1):107-14.
Genome PropertyGenProp0016: selenocysteine system (HMM)