HMM Summary Page: TIGR00474

FunctionL-seryl-tRNA(Sec) selenium transferase
Gene SymbolselA
Trusted Cutoff267.90
Domain Trusted Cutoff267.90
Noise Cutoff239.95
Domain Noise Cutoff239.95
Isology Typeequivalog
EC Number2.9.1.1
HMM Length455
Mainrole CategoryProtein synthesis
Subrole CategorytRNA aminoacylation
Gene Ontology TermGO:0004125: L-seryl-tRNASec selenium transferase activity molecular_function
GO:0016260: selenocysteine biosynthetic process biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentIn bacteria, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements: SelC is the tRNA itself, SelD acts as a donor of reduced selenium, SelA modifies a serine residue on SelC into selenocysteine, and SelB is a selenocysteine-specific translation elongation factor. 3-prime or 5-prime non-coding elements of mRNA have been found as probable structures for directing selenocysteine incorporation. This HMM describes SelA. This model excludes homologs that appear to differ in function from Frankia alni, Helicobacter pylori, Methanococcus jannaschii and other archaea, and so on.
ReferencesRN [1] RM PMID:17937620 RT Towards understanding selenocysteine incorporation into bacterial proteins. RA Fischer N, Paleskava A, Gromadski KB, Konevega AL, Wahl MC, Stark H, Rodnina MV RL Biol Chem. 2007 Oct;388(10):1061-7. DR HAMAP; MF_00423; 79 of 82
Genome PropertyGenProp0016: selenocysteine system (HMM)