Accession | TIGR00474 |
Name | selA |
Function | L-seryl-tRNA(Sec) selenium transferase |
Gene Symbol | selA |
Trusted Cutoff | 267.90 |
Domain Trusted Cutoff | 267.90 |
Noise Cutoff | 239.95 |
Domain Noise Cutoff | 239.95 |
Isology Type | equivalog |
EC Number | 2.9.1.1 |
HMM Length | 455 |
Mainrole Category | Protein synthesis |
Subrole Category | tRNA aminoacylation |
Gene Ontology Term | GO:0004125: L-seryl-tRNASec selenium transferase activity molecular_function |
| GO:0016260: selenocysteine biosynthetic process biological_process |
Author | Haft DH |
Entry Date | Apr 20 1999 2:09PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | In bacteria, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements: SelC is the tRNA itself, SelD acts as a donor of reduced selenium, SelA modifies a serine residue on SelC into selenocysteine, and SelB is a selenocysteine-specific translation elongation factor. 3-prime or 5-prime non-coding elements of mRNA have been found as probable structures for directing selenocysteine incorporation. This HMM describes SelA. This model excludes homologs that appear to differ in function from Frankia alni, Helicobacter pylori, Methanococcus jannaschii and other archaea, and so on. |
References | RN [1]
RM PMID:17937620
RT Towards understanding selenocysteine incorporation into bacterial proteins.
RA Fischer N, Paleskava A, Gromadski KB, Konevega AL, Wahl MC, Stark H, Rodnina MV
RL Biol Chem. 2007 Oct;388(10):1061-7.
DR HAMAP; MF_00423; 79 of 82 |
Genome Property | GenProp0016: selenocysteine system (HMM) |