HMM Summary Page: TIGR00470

FunctionO-phosphoserine--tRNA ligase
Gene SymbolsepS
Trusted Cutoff380.65
Domain Trusted Cutoff380.65
Noise Cutoff307.85
Domain Noise Cutoff307.85
Isology Typeequivalog
EC Number6.1.1.27
HMM Length533
Mainrole CategoryAmino acid biosynthesis
Subrole CategorySerine family
AuthorHaft DH
Entry DateApr 20 1999 2:09PM
Last ModifiedJan 9 2012 11:49AM
CommentThis family of archaeal proteins resembles known phenylalanyl-tRNA synthetase alpha chains. Recently, it was shown to act in a proposed pathway of tRNA(Cys) indirect aminoacylation, resulting in Cys biosynthesis from O-phosphoserine, in certain archaea. It charges tRNA(Cys) with O-phosphoserine. The pscS gene product converts the phosphoserine to Cys.
ReferencesSE TIGR AL clustalw RN [1] RM 15790858 RT RNA-dependent cysteine biosynthesis in archaea. RA Sauerwald A, Zhu W, Major TA, Roy H, Palioura S, Jahn D, Whitman WB, Yates JR 3rd, Ibba M, Soll D. RL Science. 2005 Mar 25;307(5717):1969-72.
Genome PropertyGenProp0304: cysteine biosynthesis, tRNA-dependent (HMM)