HMM Summary Page: TIGR00469

Functionphenylalanine--tRNA ligase
Gene SymbolpheS
Trusted Cutoff258.35
Domain Trusted Cutoff258.35
Noise Cutoff157.15
Domain Noise Cutoff157.15
Isology Typeequivalog
EC Number6.1.1.20
HMM Length451
Mainrole CategoryProtein synthesis
Subrole CategorytRNA aminoacylation
Gene Ontology TermGO:0004826: phenylalanine-tRNA ligase activity molecular_function
GO:0005739: mitochondrion cellular_component
GO:0006432: phenylalanyl-tRNA aminoacylation biological_process
GO:0009328: phenylalanine-tRNA ligase complex cellular_component
AuthorHaft DH
Entry DateApr 20 1999 2:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentUnlike all other known phenylalanyl-tRNA synthetases, the mitochondrial form demonstrated from yeast is monomeric. It is similar to but longer than the alpha subunit (PheS) of the alpha 2 beta 2 form found in Bacteria, Archaea, and eukaryotes, and shares the characteristic motifs of class II aminoacyl-tRNA ligases. This HMM models the experimental example from Saccharomyces cerevisiae (designated MSF1) and its orthologs from other eukaryotic species.
ReferencesA2 hmmalign RM Medline; 92020858; SE TIGR GA hmmls AL clustalw BD 0528