HMM Summary Page: TIGR00464

Functionglutamate--tRNA ligase
Gene SymbolgltX
Trusted Cutoff289.95
Domain Trusted Cutoff289.95
Noise Cutoff260.60
Domain Noise Cutoff260.60
Isology Typeequivalog
EC Number6.1.1.17
HMM Length470
Mainrole CategoryProtein synthesis
Subrole CategorytRNA aminoacylation
Gene Ontology TermGO:0004818: glutamate-tRNA ligase activity molecular_function
GO:0006424: glutamyl-tRNA aminoacylation biological_process
GO:0009332: glutamate-tRNA ligase complex cellular_component
AuthorHaft DH
Entry DateApr 20 1999 2:07PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe glutamyl-tRNA synthetases of the eukaryotic cytosol and of the Archaea are more similar to glutaminyl-tRNA synthetases than to bacterial glutamyl-tRNA synthetases. This HMM models just the bacterial and mitochondrial forms of the enzyme. In many species, the charging of tRNA(gln) proceeds first through misacylation with Glu and then transamidation. For this reason, glutamyl-tRNA synthetases may act on both tRNA(gln) and tRNA(glu). This model is highly specific. Proteins with positive scores below the trusted cutoff may be fragments rather than full-length sequences.
ReferencesDR EC SE TIGR GA hmmls AL clustalw DR HAMAP; MF_00022; 514 of 565
Genome PropertyGenProp0217: 5-aminolevulinate biosynthesis (glutamate pathway) (HMM)
GenProp0258: tRNA aminoacylation (HMM)
GenProp0800: bacterial core gene set, 1 or more per genome (HMM)