HMM Summary Page: TIGR00461

Functionglycine dehydrogenase
Gene SymbolgcvP
Trusted Cutoff859.20
Domain Trusted Cutoff859.20
Noise Cutoff664.70
Domain Noise Cutoff664.70
Isology Typeequivalog
EC Number1.4.4.2
HMM Length939
Mainrole CategoryEnergy metabolism
Subrole CategoryAmino acids and amines
Gene Ontology TermGO:0004375: glycine dehydrogenase (decarboxylating) activity molecular_function
GO:0019464: glycine decarboxylation via glycine cleavage system biological_process
AuthorLoftus BJ
Entry DateApr 20 1999 2:07PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis apparently ubiquitous enzyme is found in bacterial, mammalian and plant sources. The enzyme catalyzes the reaction: GLYCINE + LIPOYLPROTEIN = S-AMINOMETHYL-DIHYDROLIPOYLPROTEIN + CO2. It is part of the glycine decarboxylase multienzyme complex (GDC) consisting of four proteins P, H, L and T. Active site in E.coli is located as the (K) residues at position 713 of the SEED alignment.
ReferencesDR Swissprot; P33195; RM Medline 94237484; DR ECOCYC; EG11810; DR Swissprot; P49361; RM MEDLINE; 94218395; SE TIGR GA hmmls DR PFAM; PF02347 DR InterPro; IPR003437 DR HAMAP; MF_00711; 177 of 179