HMM Summary Page: TIGR00460

Functionmethionyl-tRNA formyltransferase
Gene Symbolfmt
Trusted Cutoff201.50
Domain Trusted Cutoff201.50
Noise Cutoff178.75
Domain Noise Cutoff178.75
Isology Typeequivalog
EC Number2.1.2.9
HMM Length315
Mainrole CategoryProtein synthesis
Subrole CategorytRNA aminoacylation
Gene Ontology TermGO:0004479: methionyl-tRNA formyltransferase activity molecular_function
GO:0005737: cytoplasm cellular_component
GO:0006431: methionyl-tRNA aminoacylation biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:07PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe top-scoring characterized proteins other than methionyl-tRNA formyltransferase (fmt) itself are formyltetrahydrofolate dehydrogenases. The mitochondrial methionyl-tRNA formyltransferases are so divergent that, in a multiple alignment of bacterial fmt, mitochondrial fmt, and formyltetrahydrofolate dehydrogenases, the mitochondrial fmt appears the most different. However, because both bacterial and mitochondrial fmt are included in the seed alignment, all credible fmt sequences score higher than any non-fmt sequence. This enzyme modifies Met on initiator tRNA to f-Met.
ReferencesSE TIGR GA hmmls AL clustalw_manual DR HAMAP; MF_00182; 452 of 467
Genome PropertyGenProp0799: bacterial core gene set, exactly 1 per genome (HMM)