| Accession | TIGR00459 |
| Name | aspS_bact |
| Function | aspartate--tRNA ligase |
| Gene Symbol | aspS |
| Trusted Cutoff | 373.85 |
| Domain Trusted Cutoff | 373.85 |
| Noise Cutoff | 317.50 |
| Domain Noise Cutoff | 317.50 |
| Isology Type | equivalog |
| EC Number | 6.1.1.- |
| HMM Length | 586 |
| Mainrole Category | Protein synthesis |
| Subrole Category | tRNA aminoacylation |
| Gene Ontology Term | GO:0004815: aspartate-tRNA ligase activity molecular_function |
| | GO:0005737: cytoplasm cellular_component |
| | GO:0006422: aspartyl-tRNA aminoacylation biological_process |
| Author | Haft DH |
| Entry Date | Apr 20 1999 2:06PM |
| Last Modified | Jan 11 2012 3:13PM |
| Comment | Asparate--tRNA ligases in this family may be discriminating (6.1.1.12) or nondiscriminating (6.1.1.23). In a multiple sequence alignment of representative asparaginyl-tRNA synthetases (asnS), archaeal/eukaryotic type aspartyl-tRNA synthetases (aspS_arch), and bacterial type aspartyl-tRNA synthetases (aspS_bact), there is a striking similarity between asnS and aspS_arch in gap pattern and in sequence, and a striking divergence of aspS_bact. Consequently, a separate model was built for each of the three groups. This HMM, aspS_bact, represents aspartyl-tRNA synthetases from the Bacteria and from mitochondria. In some species, this enzyme aminoacylates tRNA for both Asp and Asn; Asp-tRNA(asn) is subsequently transamidated to Asn-tRNA(asn). This model generates very low scores for the archaeal type of aspS and for asnS; scores between the trusted and noise cutoffs represent fragmentary sequences. |
| References | SE TIGR
GA hmmls
DR HAMAP; MF_00044; 453 of 490 |
| Genome Property | GenProp0258: tRNA aminoacylation (HMM) |
| | GenProp0799: bacterial core gene set, exactly 1 per genome (HMM) |
