HMM Summary Page: TIGR00459

Functionaspartate--tRNA ligase
Gene SymbolaspS
Trusted Cutoff373.85
Domain Trusted Cutoff373.85
Noise Cutoff317.50
Domain Noise Cutoff317.50
Isology Typeequivalog
EC Number6.1.1.-
HMM Length586
Mainrole CategoryProtein synthesis
Subrole CategorytRNA aminoacylation
Gene Ontology TermGO:0004815: aspartate-tRNA ligase activity molecular_function
GO:0005737: cytoplasm cellular_component
GO:0006422: aspartyl-tRNA aminoacylation biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:06PM
Last ModifiedJan 11 2012 3:13PM
CommentAsparate--tRNA ligases in this family may be discriminating ( or nondiscriminating ( In a multiple sequence alignment of representative asparaginyl-tRNA synthetases (asnS), archaeal/eukaryotic type aspartyl-tRNA synthetases (aspS_arch), and bacterial type aspartyl-tRNA synthetases (aspS_bact), there is a striking similarity between asnS and aspS_arch in gap pattern and in sequence, and a striking divergence of aspS_bact. Consequently, a separate model was built for each of the three groups. This HMM, aspS_bact, represents aspartyl-tRNA synthetases from the Bacteria and from mitochondria. In some species, this enzyme aminoacylates tRNA for both Asp and Asn; Asp-tRNA(asn) is subsequently transamidated to Asn-tRNA(asn). This model generates very low scores for the archaeal type of aspS and for asnS; scores between the trusted and noise cutoffs represent fragmentary sequences.
ReferencesSE TIGR GA hmmls DR HAMAP; MF_00044; 453 of 490
Genome PropertyGenProp0258: tRNA aminoacylation (HMM)
GenProp0799: bacterial core gene set, exactly 1 per genome (HMM)