HMM Summary Page: TIGR00458
| Accession | TIGR00458 |
| Name | aspS_nondisc |
| Function | aspartate--tRNA(Asn) ligase |
| Gene Symbol | aspS |
| Trusted Cutoff | 368.40 |
| Domain Trusted Cutoff | 368.40 |
| Noise Cutoff | 357.25 |
| Domain Noise Cutoff | 357.25 |
| Isology Type | equivalog |
| EC Number | 6.1.1.23 |
| HMM Length | 428 |
| Mainrole Category | Protein synthesis |
| Subrole Category | tRNA aminoacylation |
| Gene Ontology Term | GO:0004815: aspartate-tRNA ligase activity molecular_function |
| GO:0006422: aspartyl-tRNA aminoacylation biological_process | |
| Author | Haft DH |
| Entry Date | Apr 20 1999 2:06PM |
| Last Modified | Jan 11 2012 2:32PM |
| Comment | In a multiple sequence alignment of representative asparaginyl-tRNA synthetases (asnS), archaeal/eukaryotic type aspartyl-tRNA synthetases (aspS_arch), and bacterial type aspartyl-tRNA synthetases (aspS_bact), there is a striking similarity between asnS and aspS_arch in gap pattern and in sequence, and a striking divergence of aspS_bact. Consequently, a separate model was built for each of the three groups. This HMM, aspS_arch, represents aspartyl-tRNA synthetases from the eukaryotic cytosol and from the Archaea. In some species, this enzyme aminoacylates tRNA for both Asp and Asn; Asp-tRNA(asn) is subsequently transamidated to Asn-tRNA(asn). |
| References | SE TIGR GA hmmls AL clustalw DR HAMAP; MF_00044; 32 of 490 |
| Genome Property | GenProp0258: tRNA aminoacylation (HMM) |