HMM Summary Page: TIGR00458

Functionaspartate--tRNA(Asn) ligase
Gene SymbolaspS
Trusted Cutoff368.40
Domain Trusted Cutoff368.40
Noise Cutoff357.25
Domain Noise Cutoff357.25
Isology Typeequivalog
EC Number6.1.1.23
HMM Length428
Mainrole CategoryProtein synthesis
Subrole CategorytRNA aminoacylation
Gene Ontology TermGO:0004815: aspartate-tRNA ligase activity molecular_function
GO:0006422: aspartyl-tRNA aminoacylation biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:06PM
Last ModifiedJan 11 2012 2:32PM
CommentIn a multiple sequence alignment of representative asparaginyl-tRNA synthetases (asnS), archaeal/eukaryotic type aspartyl-tRNA synthetases (aspS_arch), and bacterial type aspartyl-tRNA synthetases (aspS_bact), there is a striking similarity between asnS and aspS_arch in gap pattern and in sequence, and a striking divergence of aspS_bact. Consequently, a separate model was built for each of the three groups. This HMM, aspS_arch, represents aspartyl-tRNA synthetases from the eukaryotic cytosol and from the Archaea. In some species, this enzyme aminoacylates tRNA for both Asp and Asn; Asp-tRNA(asn) is subsequently transamidated to Asn-tRNA(asn).
ReferencesSE TIGR GA hmmls AL clustalw DR HAMAP; MF_00044; 32 of 490
Genome PropertyGenProp0258: tRNA aminoacylation (HMM)