HMM Summary Page: TIGR00457

Functionasparagine--tRNA ligase
Gene SymbolasnS
Trusted Cutoff342.60
Domain Trusted Cutoff342.60
Noise Cutoff307.25
Domain Noise Cutoff307.25
Isology Typeequivalog
EC Number6.1.1.22
HMM Length455
Mainrole CategoryProtein synthesis
Subrole CategorytRNA aminoacylation
Gene Ontology TermGO:0004816: asparagine-tRNA ligase activity molecular_function
GO:0006421: asparaginyl-tRNA aminoacylation biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:06PM
Last ModifiedFeb 14 2011 3:27PM
CommentIn a multiple sequence alignment of representative asparaginyl-tRNA synthetases (asnS), archaeal/eukaryotic type aspartyl-tRNA synthetases (aspS_arch), and bacterial type aspartyl-tRNA synthetases (aspS_bact), there is a striking similarity between asnS and aspS_arch in gap pattern and in sequence, and a striking divergence of aspS_bact. Consequently, a separate model was built for each of the three groups. This HMM, asnS, represents asparaginyl-tRNA synthetases from the three domains of life. Some species lack this enzyme and charge tRNA(asn) by misacylation with Asp, followed by transamidation of Asp to Asn.
ReferencesSE TIGR GA hmmls DR HAMAP; MF_00534; 228 of 232
Genome PropertyGenProp0259: tRNA-Asn direct aminoacylation (HMM)
GenProp0258: tRNA aminoacylation (HMM)