HMM Summary Page: TIGR00457
| Accession | TIGR00457 |
| Name | asnS |
| Function | asparagine--tRNA ligase |
| Gene Symbol | asnS |
| Trusted Cutoff | 342.60 |
| Domain Trusted Cutoff | 342.60 |
| Noise Cutoff | 307.25 |
| Domain Noise Cutoff | 307.25 |
| Isology Type | equivalog |
| EC Number | 6.1.1.22 |
| HMM Length | 455 |
| Mainrole Category | Protein synthesis |
| Subrole Category | tRNA aminoacylation |
| Gene Ontology Term | GO:0004816: asparagine-tRNA ligase activity molecular_function |
| GO:0006421: asparaginyl-tRNA aminoacylation biological_process | |
| Author | Haft DH |
| Entry Date | Apr 20 1999 2:06PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | In a multiple sequence alignment of representative asparaginyl-tRNA synthetases (asnS), archaeal/eukaryotic type aspartyl-tRNA synthetases (aspS_arch), and bacterial type aspartyl-tRNA synthetases (aspS_bact), there is a striking similarity between asnS and aspS_arch in gap pattern and in sequence, and a striking divergence of aspS_bact. Consequently, a separate model was built for each of the three groups. This HMM, asnS, represents asparaginyl-tRNA synthetases from the three domains of life. Some species lack this enzyme and charge tRNA(asn) by misacylation with Asp, followed by transamidation of Asp to Asn. |
| References | SE TIGR GA hmmls DR HAMAP; MF_00534; 228 of 232 |
| Genome Property | GenProp0259: tRNA-Asn direct aminoacylation (HMM) |
| GenProp0258: tRNA aminoacylation (HMM) |