HMM Summary Page: TIGR00453

Function2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Gene SymbolispD
Trusted Cutoff181.30
Domain Trusted Cutoff181.30
Noise Cutoff87.20
Domain Noise Cutoff87.20
Isology Typeequivalog_domain
EC Number2.7.7.60
HMM Length219
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryOther
Gene Ontology TermGO:0019288: isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway biological_process
GO:0050518: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity molecular_function
AuthorHaft DH, Loftus BJ, Nelson WE
Entry DateApr 20 1999 2:06PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, the IspD protein of the deoxyxylulose pathway of IPP biosynthesis. In about twenty percent of bacterial genomes, this protein occurs as IspDF, a bifunctional fusion protein.
ReferencesDR Swissprot; Q06755; DR Blocks; UPF0007; DR EXCEPTION; EGAD|18524; CDP-ribitol pyrophosphorylase; Haemophilus influenzae DR OUTGROUP; OMNI|MT1046; UDP-N-acetylglucosamine pyrophosphorylase; Mycobacterium tuberculosis DR OUTGROUP; OMNI|CC2304; UDP-N-acetylglucosamine pyrophosphorylase; Caulobacter crescentus DR EXPERIMENTAL; SP:ISPD_ECOLI; Escherichia coli DR HAMAP; MF_01520; 70 of 79
Genome PropertyGenProp0048: IPP biosynthesis via deoxyxylulose (HMM)