HMM Summary Page: TIGR00452
| Accession | TIGR00452 |
| Name | TIGR00452 |
| Function | tRNA (mo5U34)-methyltransferase |
| Gene Symbol | cmoB |
| Trusted Cutoff | 275.00 |
| Domain Trusted Cutoff | 275.00 |
| Noise Cutoff | 150.00 |
| Domain Noise Cutoff | 150.00 |
| Isology Type | equivalog |
| EC Number | 2.1.1.- |
| HMM Length | 316 |
| Mainrole Category | Unknown function |
| Subrole Category | Enzymes of unknown specificity |
| Author | Loftus BJ, Haft DH |
| Entry Date | Apr 20 1999 2:06PM |
| Last Modified | Apr 15 2014 12:04PM |
| Comment | This model describes CmoB, the enzyme tRNA (mo5U34)-methyltransferase involved in tRNA wobble base modification. |
| References | RN [1] RM PMID:15383682 RT The modified wobble nucleoside uridine-5-oxyacetic acid in tRNAPro(cmo5UGG) promotes reading of all four proline codons in vivo. RA Nasvall SJ, Chen P, Bjork GR RL RNA. 2004 Oct;10(10):1662-73. RN [2] RM PMID:23676670 RT Structure-guided discovery of the metabolite carboxy-SAM that modulates tRNA function. RA Kim J, Xiao H, Bonanno JB, Kalyanaraman C, Brown S, Tang X, Al-Obaidi NF, Patskovsky Y, Babbitt PC, Jacobson MP, Lee YS, Almo SC RL Nature. 2013 Jun 6;498(7452):123-6. doi: 10.1038/nature12180. DR HAMAP; MF_01590; 103 of 124 |
| Genome Property | GenProp1077: tRNA(Pro) cmo5UGG modification (HMM) |