HMM Summary Page: TIGR00452

FunctiontRNA (mo5U34)-methyltransferase
Gene SymbolcmoB
Trusted Cutoff275.00
Domain Trusted Cutoff275.00
Noise Cutoff150.00
Domain Noise Cutoff150.00
Isology Typeequivalog
EC Number2.1.1.-
HMM Length316
Mainrole CategoryUnknown function
Subrole CategoryEnzymes of unknown specificity
AuthorLoftus BJ, Haft DH
Entry DateApr 20 1999 2:06PM
Last ModifiedApr 15 2014 12:04PM
CommentThis model describes CmoB, the enzyme tRNA (mo5U34)-methyltransferase involved in tRNA wobble base modification.
ReferencesRN [1] RM PMID:15383682 RT The modified wobble nucleoside uridine-5-oxyacetic acid in tRNAPro(cmo5UGG) promotes reading of all four proline codons in vivo. RA Nasvall SJ, Chen P, Bjork GR RL RNA. 2004 Oct;10(10):1662-73. RN [2] RM PMID:23676670 RT Structure-guided discovery of the metabolite carboxy-SAM that modulates tRNA function. RA Kim J, Xiao H, Bonanno JB, Kalyanaraman C, Brown S, Tang X, Al-Obaidi NF, Patskovsky Y, Babbitt PC, Jacobson MP, Lee YS, Almo SC RL Nature. 2013 Jun 6;498(7452):123-6. doi: 10.1038/nature12180. DR HAMAP; MF_01590; 103 of 124
Genome PropertyGenProp1077: tRNA(Pro) cmo5UGG modification (HMM)