HMM Summary Page: TIGR00450

FunctiontRNA modification GTPase TrmE
Gene SymboltrmE
Trusted Cutoff252.60
Domain Trusted Cutoff252.60
Noise Cutoff200.70
Domain Noise Cutoff200.70
Isology Typeequivalog
EC Number3.6.-.-
HMM Length446
Mainrole CategoryProtein synthesis
Subrole CategorytRNA and rRNA base modification
Gene Ontology TermGO:0003924: GTPase activity molecular_function
GO:0006400: tRNA modification biological_process
AuthorLoftus BJ, Haft DH
Entry DateApr 20 1999 2:10PM
Last ModifiedFeb 14 2011 3:27PM
CommentTrmE, also called MnmE and previously designated ThdF (thiophene and furan oxidation protein), is a GTPase involved in tRNA modification to create 5-methylaminomethyl-2-thiouridine in the wobble position of some tRNAs. This protein and GidA form an alpha2/beta2 heterotetramer.
ReferencesDR EXPERIMENTAL; OMNI|NTL01EC03627; Escherichia coli DR ECOCYC; EG10997; RM 10601028 RT The Escherichia coli trmE (mnmE) gene, involved in tRNA modification, codes for an evolutionarily conserved GTPase with unusual biochemical properties. RA Cabedo H, Macian F, Villarroya M, Escudero JC, Martinez-Vicente M, Knecht E, Armengod ME RL EMBO J 1999 Dec 15;18(24):7063-76 SE TIGR GA hmmls DR HAMAP; MF_00379; 519 of 542
Genome PropertyGenProp0704: tRNA U34 carboxymethylaminomethyl modification (HMM)