HMM Summary Page: TIGR00443

FunctionATP phosphoribosyltransferase, regulatory subunit
Gene SymbolhisZ
Trusted Cutoff271.65
Domain Trusted Cutoff271.65
Noise Cutoff251.60
Domain Noise Cutoff251.60
Isology Typeequivalog
HMM Length314
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryHistidine family
Gene Ontology TermGO:0000105: histidine biosynthetic process biological_process
GO:0003879: ATP phosphoribosyltransferase activity molecular_function
GO:0030234: enzyme regulator activity molecular_function
AuthorHaft DH
Entry DateApr 20 1999 2:08PM
Last ModifiedFeb 14 2011 3:27PM
CommentApparant second copies of histidyl-tRNA synthetase, found in Bacillus subtilis, Synechocystis sp., Aquifex aeolicus, and others, are in fact a regulatory subunit of ATP phosphoribosyltransferase, and usually encoded by a gene adjacent to that encoding the catalytic subunit.
ReferencesRN [1] RM PMID:15660995 RT Regulation of the hetero-octameric ATP phosphoribosyl transferase complex from Thermotoga maritima by a tRNA synthetase-like subunit. RA Vega MC, Zou P, Fernandez FJ, Murphy GE, Sterner R, Popov A, Wilmanns M RL Mol Microbiol. 2005 Feb;55(3):675-86. DR HAMAP; MF_00125; 15 of 170
Genome PropertyGenProp0109: histidine biosynthesis from ribose-5-phosphate (HMM)