| Accession | TIGR00441 |
| Name | gmhA |
| Function | phosphoheptose isomerase |
| Gene Symbol | gmhA |
| Trusted Cutoff | 209.45 |
| Domain Trusted Cutoff | 209.45 |
| Noise Cutoff | 176.20 |
| Domain Noise Cutoff | 176.20 |
| Isology Type | equivalog |
| EC Number | 5.3.1.28 |
| HMM Length | 154 |
| Mainrole Category | Cell envelope |
| Subrole Category | Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides |
| Gene Ontology Term | GO:0008968: D-sedoheptulose 7-phosphate isomerase activity molecular_function |
| | GO:0009244: lipopolysaccharide core region biosynthetic process biological_process |
| Author | Loftus BJ, Haft DH |
| Entry Date | Apr 20 1999 2:07PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This model describes phosphoheptose isomerase. Because a closely related paralo in Escherichia coli differs in function (DnaA initiator-associating protein diaA), this model has been rebuilt with a high stringency, and is likely to miss many true examples for phosphoheptose isomerase.
Involved in lipopolysaccharide biosynthesis it may have a role in virulence in Haemophilus ducreyi. |
| References | RN [1]
RM PMID:18056714
RT Structure and function of sedoheptulose-7-phosphate isomerase, a critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants.
RA Taylor PL, Blakely KM, de Leon GP, Walker JR, McArthur F, Evdokimova E, Zhang K, Valvano MA, Wright GD, Junop MS
RL J Biol Chem. 2008 Feb 1;283(5):2835-45. Epub 2007 Dec 3.
DR Swissprot; P51001
DR ECOCYC; EG13146;
SE TIGR
DR HAMAP; MF_01157; 32 of 33 |
| Genome Property | GenProp0203: LPS inner core biosynthesis, ketodeoxyoctonate and heptose type (HMM) |
