HMM Summary Page: TIGR00440

Functionglutamine--tRNA ligase
Gene SymbolglnS
Trusted Cutoff425.80
Domain Trusted Cutoff425.80
Noise Cutoff343.00
Domain Noise Cutoff343.00
Isology Typeequivalog
EC Number6.1.1.18
HMM Length524
Mainrole CategoryProtein synthesis
Subrole CategorytRNA aminoacylation
Gene Ontology TermGO:0004819: glutamine-tRNA ligase activity molecular_function
GO:0005737: cytoplasm cellular_component
GO:0006425: glutaminyl-tRNA aminoacylation biological_process
AuthorHaft DH
Entry DateApr 20 1999 2:07PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis protein is a relatively rare aminoacyl-tRNA synthetase, found in the cytosolic compartment of eukaryotes, in E. coli and a number of other Gram-negative Bacteria, and in Deinococcus radiodurans. In contrast, the pathway to Gln-tRNA in mitochondria, Archaea, Gram-positive Bacteria, and a number of other lineages is by misacylation with Glu followed by transamidation to correct the aminoacylation to Gln. This enzyme is a class I tRNA synthetase (hit by the pfam HMM tRNA-synt_1c) and is quite closely related to glutamyl-tRNA synthetases.
ReferencesSE TIGR GA hmmls AL clustalw DR HAMAP; MF_00126; 69 of 70
Genome PropertyGenProp0189: tRNA-Gln direct aminoacylation (HMM)
GenProp0258: tRNA aminoacylation (HMM)