HMM Summary Page: TIGR00434

Functionphosophoadenylyl-sulfate reductase
Gene SymbolcysH
Trusted Cutoff165.10
Domain Trusted Cutoff165.10
Noise Cutoff95.95
Domain Noise Cutoff95.95
Isology Typesubfamily
EC Number1.8.4.8
HMM Length214
Mainrole CategoryCentral intermediary metabolism
Subrole CategorySulfur metabolism
Gene Ontology TermGO:0004604: phosphoadenylyl-sulfate reductase (thioredoxin) activity molecular_function
GO:0019379: sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) biological_process
AuthorAnolik RT, Haft DH
Entry DateApr 20 1999 2:07PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme, involved in the assimilation of inorganic sulfate, is designated cysH in Bacteria and MET16 in Saccharomyces cerevisiae. Synonyms include phosphoadenosine phosphosulfate reductase, PAPS reductase, and PAPS reductase, thioredoxin-dependent. In a reaction requiring reduced thioredoxin and NADPH, it converts 3(prime)-phosphoadenylylsulfate (PAPS) to sulfite and adenosine 3(prime),5(prime) diphosphate (PAP). A related family of plant enzymes, scoring below the trusted cutoff, differs in having a thioredoxin-like C-terminal domain, not requiring thioredoxin, and in having a preference for 5(prime)-adenylylsulfate (APS) over PAPS.
ReferencesSE TIGR RN [1] RM 8917600 RT Sulfate reduction in higher plants: molecular evidence for a novel 5'-adenylylsulfate reductase. RA Setya A, Murillo M, Leustek T. RL Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13383-8. DR HAMAP; MF_00063; 86 of 92
Genome PropertyGenProp0149: sulfate reduction to sulfide, assimilatory (HMM)