| Accession | TIGR00430 |
| Name | Q_tRNA_tgt |
| Function | tRNA-guanine transglycosylase |
| Gene Symbol | tgt |
| Trusted Cutoff | 306.75 |
| Domain Trusted Cutoff | 306.75 |
| Noise Cutoff | 213.65 |
| Domain Noise Cutoff | 213.65 |
| Isology Type | equivalog |
| EC Number | 2.4.2.29 |
| HMM Length | 368 |
| Mainrole Category | Protein synthesis |
| Subrole Category | tRNA and rRNA base modification |
| Gene Ontology Term | GO:0005737: cytoplasm cellular_component |
| | GO:0006400: tRNA modification biological_process |
| | GO:0008479: queuine tRNA-ribosyltransferase activity molecular_function |
| Author | Haft DH |
| Entry Date | Apr 20 1999 2:04PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This tRNA-guanine transglycosylase (tgt) catalyzes an exchange for the guanine base at position 34 of many tRNAs; this nucleotide is subsequently modified to queuosine. The Archaea have a closely related enzyme that catalyzes a base exchange for guanine at position 15 in some tRNAs, a site that is subsequently converted to the archaeal-specific modified base archaeosine (7-formamidino-7-deazaguanosine), while Archaeoglobus fulgidus has both enzymes. |
| References | SE TIGR
GA hmmls
AL clustalw
DR HAMAP; MF_00168; 310 of 313 |
| Genome Property | GenProp0677: queuosine (Q-tRNA) biosynthesis from preQ0 (HMM) |
