HMM Summary Page: TIGR00430

FunctiontRNA-guanine transglycosylase
Gene Symboltgt
Trusted Cutoff306.75
Domain Trusted Cutoff306.75
Noise Cutoff213.65
Domain Noise Cutoff213.65
Isology Typeequivalog
EC Number2.4.2.29
HMM Length368
Mainrole CategoryProtein synthesis
Subrole CategorytRNA and rRNA base modification
Gene Ontology TermGO:0005737: cytoplasm cellular_component
GO:0006400: tRNA modification biological_process
GO:0008479: queuine tRNA-ribosyltransferase activity molecular_function
AuthorHaft DH
Entry DateApr 20 1999 2:04PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis tRNA-guanine transglycosylase (tgt) catalyzes an exchange for the guanine base at position 34 of many tRNAs; this nucleotide is subsequently modified to queuosine. The Archaea have a closely related enzyme that catalyzes a base exchange for guanine at position 15 in some tRNAs, a site that is subsequently converted to the archaeal-specific modified base archaeosine (7-formamidino-7-deazaguanosine), while Archaeoglobus fulgidus has both enzymes.
ReferencesSE TIGR GA hmmls AL clustalw DR HAMAP; MF_00168; 310 of 313
Genome PropertyGenProp0677: queuosine (Q-tRNA) biosynthesis from preQ0 (HMM)